TRAINING GRANT
Biography Disease Ecology Research in the Goldberg Lab at the University of Wisconsin–Madison focuses on the ecology‚ epidemiology, and evolution of infectious disease. We combine field and laboratory methods to understand how pathogens in dynamic ecosystems are transmitted among hosts‚ across complex landscapes‚ and over time. We also endeavor to understand how and why pathogens …
Biography Host Response We are interested in how innate T cells glycoproteins regulate immune responses. Specifically, we are investigating how natural killer T cells contribute to immunological tolerance using models of graft-vs-host disease, and we are using viral infection models (including EBV and HIV) to investigate how they switch over to promote inflammatory responses.
Biography Areas of Study Bacterial Pathogenesis, Microbiome Science, Bacteriophages Research Overview Our goal is to understand the molecular and genetic underpinnings of gut microbiome community dynamics. This work is necessary in order to build the concepts and approaches needed to cope with “problematic” microbial communities, such as those that predispose and perpetuate gastrointestinal infectious diseases. …
Biography Host Response, Translational Research Our research focuses on characterizing the molecular mechanisms that regulate cell migration, and the implications of these mechanisms to human disease, including cancer metastasis and inflammation.
Biography Viruses Our research focuses on the molecular biology of Epstein-Barr virus (EBV) nuclear proteins, their role in the virus lifecycle and the pathogenesis of EBV associated malignancies. Herpesviruses infect their hosts for life and EBV precisely manipulates growth and survival signaling pathways of B lymphocytes, resulting in their immortalization. Understanding the mechanisms that EBV …
Biography Viruses Influenza virus – molecular mechanism of interspecies transmission of the virus leading to influenza pandemics in humans; molecular pathogenesis of influenza in poultry and mammals. Ebola virus – role of viral proteins in pathogenesis and viral replication.
Biography Fungi The Keller lab research focuses on the genetic regulation of fungal secondary metabolism and development and how aberrancies in these processes affect pathogenesis. Her research led to the establishment of fungal secondary metabolite cluster motifs and the identification of conserved global regulators of secondary metabolism in fungi and how these molecules are involved …
Biography Shannon Kenney, MD Medicine, Oncology, and Medical Microbiology & Immunology skenney@wisc.edu Viruses, Host Response, Translational Research Dr. Kenney’s research effort has been focused upon understanding the molecular regulation and pathogenesis of the human herpesvirus, Epstein-Barr virus (EBV). Her work in EBV spans a broad range of topics, including viral gene regulation, the effects …
Biography Host Response, Translational Research, Fungi Molecular medical mycology — cellular and molecular basis of immunity and inflammation in response to fungi; genetics of virulence; molecular mechanisms of pathogenesis; anti-fungal drug discovery
Biography Parasitology, Immunology Our research centers on studying the host/pathogen interactions of the intracellular parasite Toxoplasma gondii. T. gondii is well known for causing encephalitis in immunocompromised patients and is a member of the coccidian family of parasites that include Plasmodium (causative agent of malaria) and Cryptosporidium (causative agent of diarrhea). My laboratory uses the …