As part of their training grant committment, each trainee gives two presentations during their grant cycle: a journal club and a presentation of their research. These seminars take place on Tuesdays at 4 p.m. and are will be held virtually until further notice. The full schedule for the 2020-21 academic year is below.
Every year, trainees select a theme for the coming year. This year the theme is:
Global Implications of Microbial Interactions
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CANCELLED September 8, 2020 - MHD Journal Club, Troy King
“Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae”
Christoph M. Ernst et. al.
https://www.nature.com/articles/s41591-020-0825-4
September 22, 2020 - MHD Journal Club, Mary Swaney
“Respiratory Bacteria Stabilize and Promote Airborne Transmission of Influenza A Virus”
Hannah M. Rowe et. al
October 6, 2020 - MHD Journal Club, Margaret Thairu
Pilar Vesga et. al.
Margaret Thairu
October 20, 2020 - MHD Journal Club, Morgan Giese
“Growth rate alterations of human colorectal cancer cells by 157 gut bacteria”
Rahwa Taddese et. al.
https://pubmed.ncbi.nlm.nih.gov/32915102/
Morgan Giese
November 3, 2020 - MHD Journal Club, Dianiris Luciano-Rosario
“Conidial Melanin of the Human-Pathogenic Fungus Aspergillus fumigatusDisrupts Cell Autonomous Defenses in Amoebae”
Iuliia Ferling et. al.
https://mbio.asm.org/content/11/3/e00862-20
Host: Dianiris Luciano-Rosario
November 17, 2020 - MHD Seminar, Mark Horton
“Evasion of innate immune response by emergent pathogen Candida auris”
Mark Horton
Graduate Student, Nett Lab
Abstract
Candida auris is an emergent fungal pathogen that causes invasive disease with a mortality rate approaching 60%. Neutrophils are innate immune cells critical for controlling many fungal infections. However, C. auris is capable of evading recognition and killing by neutrophils. C. auris has a cell wall composed of inner immunostimulatory polysaccharides such as β-glucans, which are covered by an outer layer of branched mannans on glycoproteins. We hypothesize the mannan polysaccharide layer in C. auris is poorly recognized by neutrophils and functions to mask inner β-glucans. To disrupt mannans, we generated mutants in genes which encode proteins that function early in the mannosylation pathways. Using ex vivo assays with human neutrophils, we demonstrated pmr1Δ and van1Δ mannan mutants to be 3.5-fold and 2.5-fold more susceptible to neutrophil phagocytosis, respectively, compared to the parent strain. The mutants were also more susceptible to neutrophil killing. Complementation of VAN1 reversed these phenotypes. In the zebrafish hindbrain infection model, the mannan mutants displayed decreased fungal burden compared to the parent strain. Transmission electron microscopy and 1H NMR showed a large reduction in mannan content in the mutants, and immunofluorescence microscopy showed a corresponding increase in exposed β-glucans compared to the parent strain. These studies suggest C. auris cell wall mannans participate in neutrophil evasion by masking β-glucans.
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December 1, 2020 - MHD Seminar, Troy King
MHD Seminar
Troy King
December 15, 2020 - MHD Journal Club, Lindsay Taylor
MHD Journal Club
Lindsay Taylor
February 2, 2021 - MHD Journal Club, Bryan Vonasek
MHD Journal Club
Bryan Vonasek
February 16, 2021 - MHD Seminar, Lindsay Taylor
MHD Seminar
Lindsay Taylor
March 2, 2021 - MHD Seminar, Mary Swaney
MHD Seminar
Mary Swaney
March 16, 2021 - MHD Seminar, Morgan Giese
MHD Seminar
Morgan Giese
April 6, 2021 - MHD Journal Club, Mark Horton
MHD Journal Club
Mark Horton
April 20, 2021 - MHD Seminar, Dianiris Luciano-Rosario
MHD Seminar
Dianiris Luciano-Rosario
May 4, 2021 - MHD Seminar, Margaret Thairu
MHD Seminar
Margaret Thairu
May 18, 2021 - MHD Seminar, Bryan Vonasek
MHD Seminar
Bryan Vonasek